13
Dec 2025
Normal, regulated growth of skeletal bones is a crucial part of the growth of mammals. This is a complex process involving the growth of cartilaginous cells or chondrocytes, their transformation into bone-building cells or osteoblasts, and the formation of new blood vessels to supply the newly formed bone tissue.
13
Dec 2025
Indoor dust, air and everyday products are exposing people to a growing mix of "new contaminants" inside homes, schools and workplaces, according to a new perspective published in the journal New Contaminants.
13
Dec 2025
The production of cultured meat depends on the isolation, expansion, and differentiation of animal stem cells into edible tissues. Muscle stem cells, or satellite cells, are central to this process due to their ability to regenerate and form muscle fibers.
13
Dec 2025
Before you can address a problem, you need to understand its scope. That's why the United Nations developed the Integrated Food Security Phase Classification System. Aid organizations rely on analyses from this global partnership, which monitors and classifies the severity of food insecurity to help target assistance where and when it is most needed.
13
Dec 2025
This study investigates the molecular mechanisms underlying ligand recognition, subtype selectivity, and activation of neuropeptide FF receptor 1 (NPFFR1)-a Gi/o-coupled receptor that responds to endogenous RF-amide peptides (RFRP-3 from pro-NPFFB, NPFF from pro-NPFFA) and regulates physiological processes like opioid function, pain, and energy homeostasis.
13
Dec 2025
Fibrosis, resulting from excess extracellular matrix (ECM) deposition, is a feature of adipose tissue (AT) dysfunction and obesity-related insulin resistance.
13
Dec 2025
Engineered oncolytic bacteria have emerged as a promising therapeutic platform for precision cancer treatment, offering tumor-specific colonization, immune activation, and controllable therapeutic delivery. This review summarizes recent advances in the design and application of synthetic biological strategies that enhance bacterial precision, safety, and efficacy in tumor therapy.
13
Dec 2025
DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within nucleosomes, yet their structural and functional consequences remain poorly understood due to their instability and low natural abundance.
12
Dec 2025
The American College of Lifestyle Medicine (ACLM) applauds two new Centers for Medicare and Medicaid Services (CMS) models that could significantly reshape the landscape for lifestyle medicine practice and reimbursement.
12
Dec 2025
Lowering blood sugar levels halves the likelihood of serious heart problems in people with prediabetes.
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