30
Apr 2026
Single-cell RNA sequencing is giving researchers a clearer view of why some CAR-T cells persist, expand, kill tumors effectively, or become exhausted. The review synthesizes 44 clinical scRNA-seq studies involving 500 patients and highlights how exhaustion, memory, cytotoxicity, clonal diversity, and metabolism may shape CAR-T responses.
29
Apr 2026
This review explains how glucose scarcity, lipid disruption, amino acid deprivation, and toxic metabolites weaken CAR-T cells inside solid tumors. It highlights metabolic reprogramming as a promising strategy to improve CAR-T cell persistence, adaptability, and anti-tumor function.
29
Apr 2026
A new non-invasive brain stimulation technique known as accelerated continuous theta burst stimulation (a-cTBS) improves social communication at one month follow up and has a favorable safety profile in children with autism, finds a trial from China published by The BMJ today.
29
Apr 2026
Human systems immunology is using multi-omics, single-cell tools, spatial technologies, and AI to decode immune responses across real-world human cohorts. The review highlights major opportunities for biomarker discovery and precision medicine, while stressing the need for rigorous study design, validation, and careful interpretation.
29
Apr 2026
The Nuffield Department of Women's & Reproductive Health at the University of Oxford, together with Serac Healthcare Limited announces the publication of Phase 2 data in The Lancet Obstetrics and Gynaecology.
29
Apr 2026
A large South Korean study published by The BMJ today finds no increased risk of psychiatric or neurodevelopmental disorders, such as ADHD and autism, in children whose mothers used sedative drugs (benzodiazepines or Z-hypnotics) during pregnancy.
29
Apr 2026
A large South Korean study published by The BMJ today finds no increased risk of psychiatric or neurodevelopmental disorders, such as ADHD and autism, in children whose mothers used sedative drugs (benzodiazepines or Z-hypnotics) during pregnancy.
29
Apr 2026
A large South Korean study published by The BMJ today finds no increased risk of psychiatric or neurodevelopmental disorders, such as ADHD and autism, in children whose mothers used sedative drugs (benzodiazepines or Z-hypnotics) during pregnancy.
29
Apr 2026
The responses to a national survey published today have revealed tunnel construction workers across Australia say they face significant exposure to silica dust, a hazardous dust that can cause incurable diseases like silicosis and lung cancer.
29
Apr 2026
The World Health Organization (WHO) has validated Australia for eliminating trachoma as a public health problem, marking a significant milestone in the health of Indigenous peoples and in global efforts to combat neglected tropical diseases (NTDs).
Clinical trials are very important as it allow us to evaluate the effectiveness of new drugs, new devices, preventative strategies or treatment strategies. It also enables us to discover better ways for patients' care.
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